Cytosolic phospholipase A2α reigns supreme in arthritis and bone resorption
✍ Scribed by Joseph V. Bonventre
- Book ID
- 116577537
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 335 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1471-4906
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Lipopolysaccharide (LPS)/Toll-like receptor 4 (TLR4)-mediated signaling pathways have caught the attention of strategies designed for rheumatoid arthritis (RA). In this study, we identified that cPLA 2 a acted as a modulator of LPS-induced VCAM-1 expression and THP-1 (human acute monocytic leukemia
Objective. Several lines of evidence implicate cytosolic phospholipase A 2 ␣ (cPLA 2 ␣) as a critical enzyme in inflammatory disorders, including rheumatoid arthritis. Since cells from the myeloid compartment regulate local and systemic disease pathogenesis, the present study was undertaken to exami