Cytosolic phospholipase A2α gene silencing in monocytes alters development of Th1 responses and reduces autoimmune arthritis

Cytosolic phospholipase A2α gene silenci

Cytosolic phospholipase A2α gene silencing in the myeloid lineage alters development of Th1 responses and reduces disease severity in collagen-induced arthritis

✍ G. Courties; M. Baron; J. Presumey; V. Escriou; P. van Lent; D. Scherman; A. Can 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 652 KB

Objective. Several lines of evidence implicate cytosolic phospholipase A 2 ␣ (cPLA 2 ␣) as a critical enzyme in inflammatory disorders, including rheumatoid arthritis. Since cells from the myeloid compartment regulate local and systemic disease pathogenesis, the present study was undertaken to exami