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Cytosolic phospholipase A2 as a molecular target for the radiosensitization of ovarian cancer

✍ Scribed by Rachael R. Schulte; Amanda G. Linkous; Dennis E. Hallahan; Eugenia M. Yazlovitskaya

Book ID
116335612
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
648 KB
Volume
304
Category
Article
ISSN
0304-3835

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A sensitive method for continuously monitoring the activity of the human cytosolic phospholipase \(A_{2}\) \(\left(\mathrm{cPLA}_{2}\right)\) ) is described. Recombinant cPLA \(\mathbf{A}_{2}\) efficiently hydrolyzes fatty acid esters of 7 -hydroxycoumarin, producing the free fatty acid and the high