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Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis

โœ Scribed by Joana Gil; Sandra Almeida; Catarina R. Oliveira; A.Cristina Rego

Book ID
113628983
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
397 KB
Volume
35
Category
Article
ISSN
0891-5849

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The bacterial alkaloid staurosporine is widely employed as an inducer of apoptosis in many cell types including neurons. The intracellular cascades that mediate staurosporine-induced apoptosis are largely unknown. Exposure of cultured PC12 cells to staurosporine resulted in a rapid (min) and prolong