Cytosol cathepsin-D content and proliferative activity of human breast cancer
โ Scribed by Angelo Paradiso; Anita Mangia; Mario Correale; Ines Abbate; Giovanni Ferri; Adriano Piffanelli; Laura Catozzi; Dino Amadori; Angela Riccobon; Angela Riccobon
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 743 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0167-6806
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Background. Cathepsin D is a lysosomal protease overexpressed and abnormally secreted in most breast cancer cells. Several retrospective clinical studies have shown that cathepsin D is an independent prognostic factor in breast cancer that is associated with a higher risk of recurrence and a shorter
## Abstract Cathepsin D was assayed in 74 primary breast cancer specimens by enzyme immunoassay (EIA) and immunohistochemical assay (ICA). Of the 74 specimens, 38 (51.4%) were scored positive by ICA, and 25 (33.8%) were scored positive by EIA. The coincidence rate between ICA and EIA was 71.6% (53/