Cytoskeleton and Small G Proteins

✍ Scribed by Anne J. Ridley (auth.), Professor Dr. Philippe Jeanteur (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1999
• Tongue: English
• Leaves: 241
• Series: Progress in Molecular and Subcellular Biology 22
• Edition: 1
• Category: Library

✦ Synopsis

The internal structure of a cell can be affected by signals in the form of small molecules outside the cell. These changes can then alter the shape or adhesiveness of the cell. This volume centers particularly on one family of cellular proteins which transmit these signals, the Rho Ras-like GTPases, and examines their role in normal cellular processes and development. Also discussed are their roles in cancer formation and microbial pathogenesis.

✦ Table of Contents

Front Matter....Pages I-XII
Rho Family Proteins and Regulation of the Actin Cytoskeleton....Pages 1-22
Regulation of Cytoskeleton and Cell Adhesion by Rho Targets....Pages 23-38
Rnd Proteins: A New Family of Rho-Related Proteins That Interfere with the Assembly of Filamentous Actin Structures and Cell Adhesion....Pages 39-50
The DH Protein Family, Exchange Factors for Rho-Like GTPases....Pages 51-83
RhoGAPs and RhoGDIs, (His)stories of Two Families....Pages 85-113
Roles of PAK Family Kinases....Pages 115-133
Rac and Cdc42 Effectors....Pages 135-158
Small GTPases of the Rho Family and Cell Transformation....Pages 159-181
Rho GTP-Binding Proteins as Targets for Microbial Pathogens....Pages 183-199
Rho GTPases in Development....Pages 201-229
Back Matter....Pages 231-234

✦ Subjects

Cell Biology; Biochemistry, general; Cancer Research