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Cytoskeletal myotoxicity from simvastatin and colchicine

โœ Scribed by Steven K. Baker; Susan Goodwin; Monalisa Sur; Mark A. Tarnopolsky


Book ID
102537452
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
219 KB
Volume
30
Category
Article
ISSN
0148-639X

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Alterations of choline acetyltransferase
โœ Krystyna Kolasa; Richard S. Jope; M. Shane Baird; Gail V. W. Johnson ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 582 KB

Colchicine, a microtubule disrupting toxin, was administered intracerebroventricularly to rats, followed by measurements of (i) the activity of choline acetyltransferase, a biochemical marker of cholinergic neurons, (ii) cytoskeletal protein concentrations, including tau, MAP-2, spectrin, and tubuli