𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cytoskeletal-associated proteins in the migration of cortical neurons

✍ Scribed by Bielas, Stephanie L. ;Gleeson, Joseph G.

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
232 KB
Volume
58
Category
Article
ISSN
0022-3034

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Neuronal migration is a hallmark of cerebral cortical development as neurons born deep within the brain migrate to the surface in a highly choreographed process. The cytoskeleton extends throughout the cell, mediating the dramatic morphological changes that accompany migration. On a cellular level, proper migration is accompanied by polarization of the cytoskeleton and cellular contents and by dynamic reorganization that generates the force for cell locomotion. Genetic analyses of human brain malformations, as well as genetically engineered mouse mutants, have highlighted a number of cytoskeletal‐associated proteins underlying these functions, which are necessary for proper cortical development. While these proteins are involved in diverse molecular mechanisms, disruption during development results in the ectopic placement of neurons in the cortex. We review key cytoskeletal events and the critical cytoskeletal‐associated proteins involved in cortical neuronal migration. © 2003 Wiley Periodicals, Inc. J Neurobiol 58: 149–159, 2004

📜 SIMILAR VOLUMES

Dynamic behavior and organization of cyt
Dynamic behavior and organization of cytoskeletal proteins in neurons: reconciling old and new findings
✍ Ralph A. Nixon 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 274 KB

Neurons are faced with the formidable challenge of having to assemble most of their cytoskeleton at axonal sites far removed from the protein synthetic machinery in the perikaryon. Their achievement seems all the more impressive now that new evidence is showing that the cytoskeleton may vary markedl

Effect of phenytoin on cytoskeletal prot
Effect of phenytoin on cytoskeletal protein phosphorylation and neuronal structure in the rat sensory cortex
✍ G. Ruiz; O. G. Flores; R. González-Plaza; N. C. Inestrosa 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 639 KB

Phenytoin (PH) is commonly used as an anticonvulsant drug, and it causes several collateral effects including morphological changes in brain cortex neurons and teratogenic lesions in infants of epileptic mothers. Several lines of evidence indicate that PH may exert its action through the modificatio

Regional variation in the abundance of a
Regional variation in the abundance of axonal cytoskeletal proteins
✍ D. Watson 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 623 KB

## Abstract The relative abundance of several axonal cytoskeletal proteins was determined by immunoassay at various sites in the peripheral and central nervous systems of adult rats. Within the peripheral nervous system, the ratio of tubulin to neurofilaments was greatest for nerves composed of unm

The effect of insulin on proteins associ
The effect of insulin on proteins associated with free, cytoskeletal-bound and membrane-bound polysome populations.
✍ Rigmor Moss; Ian F. Pryme; Anni Vedeler 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 535 KB

## Abstract It is known that insulin treatment increases the rate of protein synthesis in many cells and tissues and that it causes changes in the distribution of ribosomes between free (FP), cytoskeletal‐bound (CBP) and membrane‐bound polysome (MBP) populations. This paper concerns an analysis of

Genetics of neuronal migration in the ce
Genetics of neuronal migration in the cerebral cortex
✍ Walsh, Christopher A. 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB 👁 2 views

The development of the cerebral cortex requires large-scale movement of neurons from areas of proliferation to areas of differentiation and adult function in the cortex proper, and the patterns of this neuronal migration are surprisingly complex. The migration of neurons is affected by several natur