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Cytosine deaminase versus thymidine kinase: a comparison of the antitumor activity

✍ Scribed by H. Corban-Wilhelm; G. Becker; U. Bauder-Wüst; D. Greulich; J. Debus

Book ID
106300233
Publisher
Springer
Year
2003
Tongue
English
Weight
127 KB
Volume
3
Category
Article
ISSN
0372-8722

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Prostate tumor cells (PC-3) were transduced with defective, recombinant adenovirus containing a fusion gene encoding the Escherichia coli cytosine deaminase and herpes simplex virus type-1 thymidine kinase under the control of a cytomegalovirus promoter. Expression levels of the fusion protein were