Cytoreductive surgery impedes metastasis and enhances the immune response: A preliminary report

✍ Scribed by Gedas Grinis; Paul Targonski; Michael Shaw; Marvin Rubenstein; Patrick D. Guinan

• Book ID: 102437778
• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 413 KB
• Volume: 48
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930480210

✦ Synopsis

In an effort to determine the effect of cytoreductive surgery on the metastatic process, MAT-LyLu flank tumors were excised from Copenhagen X Fischer rats and the effects of this surgery on metastatic lung lesions were observed. Cytoreduction resulted in a decrease in lung lesions ( P < 0.05).

Adjuvant cyclophosphamide (CTX) further enhanced this beneficial effect. A concurrent increase in the helper/suppressor ratios suggested that this beneficial response might be mediated by the host's immune response.