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Cytoprotective effect of gallotannin in oxidatively stressed HaCaT keratinocytes: the role of poly(ADP-ribose) metabolism

✍ Scribed by Edina Bakondi; Péter Bai; Katalin Erdélyi; Csaba Szabó; Pál Gergely; László Virág

Book ID
110755032
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
1006 KB
Volume
13
Category
Article
ISSN
0906-6705

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## Abstract Continuously generated hydrogen peroxide (H~2~O~2~) inhibits typical apoptosis and instead initiates a caspase‐independent, apoptosis‐inducing factor (AIF)‐mediated pyknotic cell death. This may be related to H~2~O~2~‐mediated DNA damage and subsequent ATP depletion, although the exact