Nuclear-cytoplasmic transport of EGFR in
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Hui-Wen Lo; Mohamed Ali-Seyed; Yadi Wu; Geoffrey Bartholomeusz; Sheng-Chieh Hsu;
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Article
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2006
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John Wiley and Sons
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English
β 550 KB
## Abstract Many receptor tyrosine kinases (RTKs) can be detected in the cell nucleus, such as EGFR, HERβ2, HERβ3, HERβ4, and fibroblast growth factor receptor. EGFR, HERβ2 and HERβ4 contain transactivational activity and function as transcription coβfactors to activate gene promoters. High EGFR in