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Cytoplasmic tall of the T-cell receptor α-chain is involved in down-regulation, but not signalling

✍ Scribed by B.Thomas Báckstróm; Bent Rubin; Annick Peter; Georg Tiefenthaler; Ed Palmer


Book ID
108408651
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
364 KB
Volume
56
Category
Article
ISSN
0165-2478

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T cell receptor α-chain tail is required
✍ B. Thomas Bäckström; Bent Rubin; Annick Peter; Georg Tiefenthaler; Ed Palmer 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 992 KB

## Abstract Antigen stimulation through the T cell receptor (TCR) induces phosphorylation of the associated CD3 γδσ‐ and ζ‐chain cytoplasmic tails. These events lead to the induction of the intracellular signaling pathways with concomitant receptor down‐regulation. The TCR is down‐regulated from th