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Cytoplasmic gelsolin increases mitochondrial activity and reduces Aβ burden in a mouse model of Alzheimer's disease

✍ Scribed by Desiree Antequera; Teo Vargas; Cristina Ugalde; Carlos Spuch; Jose Antonio Molina; Isidro Ferrer; Felix Bermejo-Pareja; Eva Carro


Book ID
113812369
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
587 KB
Volume
36
Category
Article
ISSN
0969-9961

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## Abstract ## Purpose To demonstrate an MRI method for directly visualizing amyloid‐β (Aβ) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T~1ρ~ relaxation rate increases progressively with Alzheimer's disease (AD)‐related pathology in the tg mouse brain. ## Materials a