Cytolytic response of human T cells against allogeneic small cell lung carcinoma treated with interferon gamma

✍ Scribed by P. Weynants; P. Wauters; P. G. Coulie; B. Eynde; M. Symann; T. Boon

• Publisher: Springer-Verlag
• Year: 1988
• Tongue: English
• Weight: 458 KB
• Volume: 27
• Category: Article
• ISSN: 0340-7004
• DOI: 10.1007/bf00205444

✦ Synopsis

Human lymphocytes stimulated in vitro by allogeneic small cell lung carcinoma cell lines did not show any significant cytolytic activity against the stimulator tumor cells. However, a high level of lysis was observed when both stimulator and target small cell lung carcinoma cells were pretreated with interferon gamma, which increased considerably the expression of major histocompatibility class I molecules by these cells. The demonstration that small cell lung carcinoma cells can be lysed by cytolytic T lymphocytes, suggests that it will be feasible to study the autologous T cell response of patients against this tumor.