## Background: Prostatic intraepithelial neoplasia (pin) is the most likely precursor of prostatic adenocarcinoma. however, the ultrastructural features of pin have not been defined in properly fixed tissues. ## Methods: In this study, we examined a total of 84 acini from 11 cases of high-grade p
Cytological features of prostatic intraepithelial neoplasia
β Scribed by Alexander Valdman; Sara Jonmarker; Peter Ekman; Lars Egevad
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 489 KB
- Volume
- 34
- Category
- Article
- ISSN
- 8755-1039
- DOI
- 10.1002/dc.20417
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## Abstract ## Purpose This study was conducted to evaluate the transrectal sonographic (TRUS) features of prostatic intraepithelial neoplasia (PIN) by comparing the histopathologic results with TRUS findings in patients who had undergone TRUSβguided prostate biopsy. ## Methods From an initial s
Putative premalignant changes in the prostate have been recognized for a number of years. A variety of synonyms have been given to the most commonly described lesion, characterized by proliferation and dysplasia of the normal two cell layers lining prostatic acini and ductules; prostatic intraepithe
Our group has been studying the progressive molecular changes in prostatic epithelium which precede the invasive phenotype. Initial studies revealed similar alterations in cytoskeletal proteins between high grade prostatic intraepithelial neoplasia (PIN) lesions and invasive carcinoma. Specifically
## BACKGROUND. The search for the precursor of prostatic adenocarcinoma has focused in recent years on two histopathologic-findings: high grade prostatic intraepithelial rieoplasia (PIN) and atypical adenorriatous hyperplasia ( M I . This article describes the diagnostic criteria and clinical sign