Cytologic features of deep juvenile xanthogranuloma

✍ Scribed by Ronald T. Grenko; Joshua Z. Sickel; Catherine S. Abendroth; Robert E. Cilley

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 720 KB
• Volume: 15
• Category: Article
• ISSN: 8755-1039
• DOI: 10.1002/(sici)1097-0339(199611)15:4<329::aid-dc15>3.0.co;2-q

✦ Synopsis

Juvenile xanthogranuloma (JXG) is a rare lesion of the skin and deep tissues whose cytologic features have not previously been published. We report on 2 cases of JXG in patients aged 5 days and 5 yr who presented with an axillary mass and enlarged supraclavicular lymph node, respectively. Fine-needle aspiration and touch imprints made from the surgical biopsies yielded cellular specimens composed of histiocytes, multinucleated Touton-type giant cells, and variable admixtures of lymphocytes and eosinophils. One lesion was composed primarily of benignappearing histiocytes with aahixed multinucleated giant cells and a f a v lymphocytes. The second lesion consisted of a few histiocytes, occasional Touton giant cells, many lymphocytes

, and scatteredfibroblasts. The histiocytes were CD68-positive and S l Oo-nrgative. Histologic follow-up confirmed the diagnosis of juvenile xanthogranuloma. One patient was lost to follow-up: the other is alive without evidence of recurrence 1 yr afer surgery. We conclude that deep JXG has characteristic and diagnostic cytologic features.