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Cytologic evaluation of cyclin D1 expression in primary breast carcinoma

✍ Scribed by Park, Kyeongmee ;Han, Sehwan ;Kim, Hong-Yong ;Ko, Ilhyang

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 189 KB
Volume: 93
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.9031

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

Preoperative assessment of the biologic characteristics of primary breast carcinoma is important because neoadjuvant medical therapy is being used increasingly. In the current study, the authors attempted to evaluate the validity of cyclin D1 assay in fine-needle aspiration (FNA) samples from patients with primary breast carcinoma.

METHODS.

FNA samples were obtained prior to therapy and multiple slides were stored at -80 °C for subsequent immunocytochemical analysis (ICA). ICA for cyclin D1 protein was performed on FNA samples from 51 breast carcinoma patients and 20 samples from patients with benign breast disease. In 45 breast carcinoma patients who had undergone surgery, sections were taken from paraffin blocks and stained by ICA for cyclin D1 validation. Possible correlations between cyclin D1 expression in the FNA samples and the biologic data of the patients also were analyzed.

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