Cytologic and DNA-cytometric follow-up of oral leukoplakia after CO2- and Er:YAG-laser assisted ablation: A pilot study
✍ Scribed by Frank Schwarz; Dimitra Maraki; Sebnem Yalcinkaya; Katrin Bieling; Alfred Böcking; Jürgen Becker
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 210 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0196-8092
No coin nor oath required. For personal study only.
✦ Synopsis
Background and objectives:
The aim of the present pilot study was to determine therapeutic responses to er:yag- and co(2)-laser ablation in patients with oral leukoplakia as evaluated by means of exfoliative cytology (ec) and dna-image-cytometry (dna-i).
Study design/materials and methods:
Ten patients exhibiting a total of 16 lesions affecting a variety of intraoral sites were randomly treated with either (1) an er:yag laser (300 mj/pulse, 10 hz, defocused mode) (erl), or (2) an co(2) laser (4-6 w, 20-50 hz, focused mode) (co). brush (b) and incisional (i) biopsies were obtained from the respective lesions immediately before treatment (b, i) as well as 24-96 weeks postoperatively (b). in cases, in which ec revealed suspicious cells, nuclear dna-contents were measured using a tv image analysis system.
Results:
Both treatment approaches resulted in a complete (c) or partial (p) remission of all investigated lesions. in particular, erl exhibited c(3), p(5), and co c(5), p(3). however, in the co group, two of eight lesions showed a recurrence 32-48 weeks following treatment. among all investigated lesions, both histological and ec/dna-i diagnosis revealed no sign of malignancy or dysplasia before or following laser assisted ablation.
Conclusions:
Within the limits of the present study, it may be concluded that both treatment approaches seem to have limitations to achieve predictable eradication of oral leukoplakia.