Cytokines Regulate Matrix Metalloproteinases in Human Uterine Endometrial Fibroblast Cells Through a Mechanism That Does Not Involve Increases in Extracellular Matrix Metalloproteinase Inducer

Mast cell tryptase does not alter matrix

Mast cell tryptase does not alter matrix metalloproteinase expression in human dermal fibroblasts: Further evidence that proteolytically-active tryptase is a potent fibrogenic factor

✍ Jianhua Zhang; Barry L. Gruber; Mary J. Marchese; Stanley Zucker; Lawrence B. Sc 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 226 KB

There is compelling in vitro and in vivo evidence to implicate mast cells in the development of fibrosis. However, an important question remains as to the mechanisms by which mast cells mediate fibrosis. Recent evidence from our laboratory (Gruber et al., 1997, J. Immunol., 158:2310 -2317) has revea