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Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5′-deoxy-5-fluorouridine

✍ Scribed by Hiroyuki Eda; Kaori Fujimoto; Shin-ichi Watanabe; Masako Ura; Ayako Hino; Yutaka Tanaka; Kenji Wada; Hideo Ishitsuka

Book ID: 104917909
Publisher: Springer
Year: 1993
Tongue: English
Weight: 724 KB
Volume: 32
Category: Article
ISSN: 0344-5704
DOI: 10.1007/bf00735915

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Thymidine phosphorylase (dThdPase) is an essential enzyme for the activation of the oral cytostatic drugs capecitabine (N 4 -pentyloxycarbonyl-5Ј-deoxy-5-fluorocytidine, Xeloda ) and its intermediate metabolite doxifluridine [5Ј-deoxy-5-fluorouridine (5Ј-dFUrd, Furtulon )] to 5-fluorouracil (5-FUra)