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Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5′-deoxy-5-fluorouridine

✍ Scribed by Hiroyuki Eda; Kaori Fujimoto; Shin-ichi Watanabe; Masako Ura; Ayako Hino; Yutaka Tanaka; Kenji Wada; Hideo Ishitsuka


Book ID
104917909
Publisher
Springer
Year
1993
Tongue
English
Weight
724 KB
Volume
32
Category
Article
ISSN
0344-5704

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Induction of thymidine phosphorylase exp
✍ Mika Endo; Noriko Shinbori; Yu Fukase; Noriaki Sawada; Tohru Ishikawa; Hideo Ish 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 239 KB 👁 2 views

Thymidine phosphorylase (dThdPase) is an essential enzyme for the activation of the oral cytostatic drugs capecitabine (N 4 -pentyloxycarbonyl-5Ј-deoxy-5-fluorocytidine, Xeloda ) and its intermediate metabolite doxifluridine [5Ј-deoxy-5-fluorouridine (5Ј-dFUrd, Furtulon )] to 5-fluorouracil (5-FUra)