Many viruses have evolved novel means of exploiting host defense mechanisms for their own survival. This exploitation may be best exemplified by the interrelationships between certain viruses and the host cytokine networks. Many viruses, including the human immunodeficiency virus type-I (HIV-1 ), re
Cytokines in viral diseases
β Scribed by Iain L Campbell
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 887 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0952-7915
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β¦ Synopsis
As in many other areas of cytokine biology, recent studies of the role of cytokines in viral disease reveal numerous complex interactions that in many instances may contribute directly to the development of pathology. For example, data from the rapidly evolving field of human retrovirology has shown that these viruses, as well as inducing the expression of many cellular cytokine genes, can be activated from latency and driven into replication/expression by the very same cytokines. The continuing rapid expansion of knowledge in the cytokine area augers well for eventual development of novel antiviral therapeutic strategies based on manipulation of the cytokine network.
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## Abstract Cytokines, the polypeptide mediators of the immune system, were shown to exert numerous actions on endocrine functions. Bidirectional links based on the sharing of mediators and receptors between the immune and neuroendocrine systems lead to the concept of the immuneβneuroendocrine syst