Cytokines IL-1α, IL-6, and GM-CSF constitutively secreted by oral squamous carcinoma induce down-regulation of CD80 costimulatory molecule expression: restoration by interferon γ

IL-12- and IL-2-induced tumor regression

IL-12- and IL-2-induced tumor regression in a new murine model of oral squamous-cell carcinoma is promoted by expression of the CD80 co-stimulatory molecule and interferon-γ

✍ Giovana R. Thomas; Zhong Chen; Ileana Enamorado; Caren Bancroft; Carter Van Waes 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 313 KB 👁 2 views

Therapy with IL-12 or IL-2 induces tumor regression in only a few patients with head-and-neck squamous cell carcinoma (SCC), and the factors promoting responsiveness have not been well defined. In this study, we examined whether combined IL-12 and IL-2 therapy can induce tumor regression in a new mu