✦ LIBER ✦

Cytokines and cancer: experimental systems

✍ Scribed by Thomas Blankenstein; Donald A. Rowley; Hans Schreiber

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 660 KB
Volume: 3
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(91)90098-l

No coin nor oath required. For personal study only.

✦ Synopsis

The transfer of certain cytokine genes into cancer cells can provide very powerful suppression of tumor growth in the absence of any toxic side effects. Some of these cytokines, such as interleukin-4, granulocyte colony-stimulating factor and tumor necrosis factor, can mediate powerful immune suppression even in T-cell-deficient animals and appear to be effective for poorly or non-antigenic tumors. However, approaches must be found to induce or deliver cytokines locally at the tumor site.

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