Cytokines activate genes of the endocytotic pathway in insulin-producing RINm5F cells
β Scribed by K. L. A. Souza; M. Elsner; P. C. F. Mathias; S. Lenzen; M. Tiedge
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 246 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0012-186X
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## Abstract Xβray microanalysis was used to detect elemental changes in the insulinβproducing tumor cellβline RINm5F. To improve discrimination between mobile ions and ions bound to macromolecules a new approach was employed, consisting of multivariate statistical analysis of correlations between t
Thyrotropin-Releasing hormone (TRH)-degrading pyroglutamyl peptidase I (PGP I) and prolylendopeptidase (PE) activities have been demonstrated in rat insulinoma RINm 5F cell line. These two enzymes catalyze the conversion of TRH to Histydyl-Proline-Diketopiperazine and to acid TRH respectively. After