Cytokine-mediated alterations in host metabolism prevent nutritional repletion in cachectic cancer patients

✍ Scribed by N. Joseph Espat; Lyle L. Moldawer; Edward M. Copeland III

• Book ID: 102924299
• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 630 KB
• Volume: 58
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930580202

✦ Synopsis

The clinical syndrome of cachexia is characterized by anorexia, continued losses of lean body mass, and altered carbohydrate and lipid metabolism. As early as the 1930s, this "chronic wasting" syndrome had been identified as the most frequent immediate cause of death in patients with cancer [Warren: Am J Med Sci 184:61&619, 19321. At present, controversy remains as to the benefit of supplemental parenteral or enteral feedings in the nutritional repletion of cachectic cancer patients, since only selected patient groups have demonstrated clear benefit from their administration [