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CYTOKINE-INDUCED IMPAIRMENT OF SHORT-CHAIN FATTY ACID OXIDATION AND VIABILITY IN HUMAN COLONIC EPITHELIAL CELLS

✍ Scribed by G Pedersen; T Saermark; T Horn; B Giese; K Bendtzen; J Brynskov

Book ID
115596555
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
385 KB
Volume
12
Category
Article
ISSN
1043-4666

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LIM1215 colon cancer cells were used as a model of human colonic epithelium to examine the effects of butyrate on protein kinase C (PKC) activity and isoform expression. On Western blot analysis, LIM1215 cells express the PKC isoforms ␣, ␀, , , and , but not β₯, , or . Treatment with 2 mM butyrate fo