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Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase

✍ Scribed by Elizabeth C. Arner; Clare E. Hughes; Carl P. Decicco; Bruce Caterson; Micky D. Tortorella

Book ID
114476044
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
392 KB
Volume
6
Category
Article
ISSN
1063-4584

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## Abstract The significance of T‐cell activation in the immunopathogenesis of articular disease has been studied in an in vitro model to assess the capacity of phytomitogen‐induced lymphokines to degrade cartilage matrix proteoglycans. Supernatants derived from T‐cell activation of normal human pe