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CYTOKINE- AND NEUROPEPTIDE-MEDIATED DIFFERENTIATION IN RETINAL PIGMENT EPITHELIAL CELLSIN VITRO

✍ Scribed by HIROKO KISHI; HIROMU K. MISHIMA; UKI YAMASHITA

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
133 KB
Volume
21
Category
Article
ISSN
1065-6995

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✦ Synopsis

To determine the mechanism of growth and differentiation of retinal pigment epithelial (RPE) cells it is important to understand the pathogenesis of several retinal diseases. Recently it has been reported that several cytokines and neuropeptides regulate the growth of RPE cells. In this study, the role of cytokines and neuropeptides in melanin synthesis, which is one indication of the RPE cell differentiation, was examined using chick RPE cells in vitro. IL-1 , TNF-, substance P, -endorphin and methionine-enkephalin stimulated the melanin synthesis of RPE cells in a dose-dependent manner. The most effective concentrations of these agents on RPE cell melanin synthesis were not the same as that for RPE cell proliferation. These results indicate that cytokines and neuropeptides play an important role not only for the growth but also for the differentiation of RPE cells.

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