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Cytokine-activated Jak-2 is involved in inducible nitric oxide synthase expression independent from NF-κB activation in vascular smooth muscle cells

✍ Scribed by Masaru Doi; Masayoshi Shichiri; Koichi Katsuyama; Shinya Ishimaru; Yukio Hirata

Book ID: 119435362
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 249 KB
Volume: 160
Category: Article
ISSN: 0021-9150
DOI: 10.1016/s0021-9150(01)00578-0

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## Abstract Expression of inducible nitric oxide synthase (iNOS), which leads to the production of nitric oxide (NO), is stimulated by proinflammatory cytokines such as interleukin‐1β (IL‐1β) and tumor necrosis factor‐α (TNF‐α). Here we report on the roles of nuclear factor‐κB (NF‐κB) and mitogen‐a