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Cytokeratin 19 fragments: A new marker for non-small-cell lung cancer

✍ Scribed by Petra Stieber; Heinz Bodenmüller; Dieter Banauch; Ute Hasholzner; Andreas Dessauer; Beatus Ofenloch-Hähnle; Dieter Jaworek; Ahmad Fateh-Moghadam

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
360 KB
Volume
26
Category
Article
ISSN
0009-9120

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✦ Synopsis

We developed a new and automated assay for the detection of lung cancer associated cytokeratin 19 fragments in patients' sera/plasma. This new tumour marker assay CYFRA 21-1 was evaluated in technical and clinical studies using the multibatch analysers ES 300 and ES 600 from Boehringer Mannheim GmbH. The analytical performance was shown to be excellent. The clinical data from 2,037 patients demonstrate that for nonsmall-cell lung carcinoma CYFRA 21-1 has a higher diagnostic sensitivity compared to the established markers. Mainly for squamous cell carcinoma CYFRA 21-1 was superior (60%) to CEA (18%) or SCC (31%),

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