Cytogenetics of the Chronic Myeloid Leukemia-Derived Cell Line K562: Karyotype Clarification by Multicolor Fluorescence In Situ Hybridization, Comparative Genomic Hybridization, and Locus-Specific Fluorescence In Situ Hybridization
β Scribed by Susan M Gribble; Ian Roberts; Colin Grace; Kathryn M Andrews; Anthony R Green; Elizabeth P Nacheva
- Book ID
- 114137021
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 402 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0165-4608
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We used comparative genomic hybridization (CGH) to identify a number of previously undescribed chromosomal imbalances in K-562, a spontaneously transformed cell line originally derived from leukemic cells of a chronic myeloid leukemia (CML) patient in blast crisis. Noteworthy were a discrete amplifi