Prenatal diagnosis is now available to fragile X (fra[X]) syndrome families and has proven reliable when testing male fetuses. It has been reported that approximately one-third of heterozygous fra(X) females demonstrate mental impairment. Based on this, families usually continue pregnancies involvin
✦ LIBER ✦
Cytogenetically negative, linkage positive “fragile X” syndrome
✍ Scribed by Brooks, Susan Sklower ;Cohen, Ira ;Ferrando, Charles ;Jenkins, Edmund C. ;Brown, W. Ted ;Dobkin, Carl
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 555 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0148-7299
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Linkage data using the markers F9 (factor IX), DXS15 (DX131, and DXS134 (cpX67) are presented from 26 pedigrees segregating with fragile X (fra[XI) syndrome. Cytogenetic and DNA data were combined in 2-point linkage analysis for the estimation of lod scores and carrier probabilities in potential car