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Cytogenetic studies on B-cell leukemias of akr origin

โœ Scribed by Luba Trakhtenbrot; Alpha Peled; Nechama Haran-Ghera

Book ID
102863912
Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
834 KB
Volume
39
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

The karyotype of B-cell leukemias of AKR origin was studied by G-banding. In contrast to previous observations indicating trisomy of chromosome 15 in spontaneous and chemicallyinduced B-cell leukemias, I I out of I S tumors analyzed had normal diploid karyotypes. Four tumors with the modal number 39-41 had different chromosome markers specific for each tumor. The possible correlation between non-random chromosomal changes and the target cell involved in the initial transformation in AKR leukemogenesis is discussed.

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## Abstract Four combinations of translocation heterozygotes with cytogenetically distinct chromosomes 15 were used to investigate whether the Tโ€cell leukemiaโ€associated preferential duplication of the AKRโ€derived chromosome 15 (AKRโ€15) is determined by factors within this chromosome, or is due to