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Cytogenetic studies of breast carcinomas

✍ Scribed by Margrét Steinarsdóttir; Ingibjörg Pétursdóttir; Kesara Anamthawat-Jónsson


Book ID
119106340
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
104 KB
Volume
77
Category
Article
ISSN
0165-4608

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Cytogenetic studies of breast carcinomas
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Chromosome analysis was performed on samples from 85 consecutive patients with breast cancer by one or more of three different methods: direct harvest, culture after mechanical disaggregation, and culture after coltagenase digestion. Metaphases suitable for karyotyping were obtained in 70% of the ca

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In this study, we compared genetic instability in 70 breast carcinomas analyzed by two different methods, cytogenetics and flow cytometry. This comparison showed that each method has its strengths and weaknesses. Flow cytometry detected aneuploidy in 60% of cases, but missed most of the cytogenetica