Cytogenetic studies of adipose tissue tumors. I. A benign lipoma with reciprocal translocation t(3;12)(q28;q14)

✍ Scribed by Claude Turc-Carel; Paola Dal Cin; Uma Rao; Constantine Karakousis; Avery A. Sandberg

• Book ID: 119103146
• Publisher: Elsevier Science
• Year: 1986
• Tongue: English
• Weight: 630 KB
• Volume: 23
• Category: Article
• ISSN: 0165-4608
• DOI: 10.1016/0165-4608(86)90010-5

✦ Synopsis

Detailed clinical histories and cytogenetic investigations using short-term cultures are reported in three typical benign lipomas. Although a diploid (normal) karyotype was observed in two cases, a reciprocal chromosome translocation t(3;12)(q28;q14) was found in the third case, which was briefly reported previously. These data are discussed in light of a lipoma with similar karyotypic changes reported by Heim et al. and a similar translocation observed by us in malignant myxoid liposarcomas. The nonrandom involvement of segment 12q13-q14 in benign and malignant lipomatous tumors suggest a common basis for at least one of the possible multiple steps in the genesis of neoplastic processes.