Cytogenetic studies in human sperm

✍ Scribed by A. M. Estop; K. Cieply; V. Vankirk; S. Munne; K. Garver

• Book ID: 104659550
• Publisher: Springer
• Year: 1991
• Tongue: English
• Weight: 583 KB
• Volume: 87
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00197166

✦ Synopsis

Sperm chromosome studies were performed in seven males. One of them had a history of exposure to lysergic acid (LSD) although he was free of the drug for 1 year before the study began. Sixteen ejaculates provided a total of 555 fully analyzable sperm cells. The overall frequency of hyperhaploid sperm cells was 2% and that of structural abnormality 3.6%. The most common structural abnormality was chromosome breaks followed by small chromosome fragments of unknown origin. Three chromosome breakpoints, 10@5, 2@1, and 9q21, were involved twice in different chromosome or chromatid type aberrations. Two of these, 10q25 and 2q21, correspond to chromosomal locations known as common fragile sites.