Cytogenetic studies in four cases of Acute Promyelocytic Leukemia (APL)
β Scribed by Koji Kondo; Motomichi Sasaki
- Book ID
- 119102440
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 482 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0165-4608
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## Abstract A series of 105 patients with acute promyelocytic leukemia (APL) has been cytogenetically investigated at the Department of Hematology of the SaintβLouis Hospital (Paris) between 1977 and 1990. Sixtyβtwo patients were examined at diagnosis, 32 in relapse, and 11 both at diagnosis and in
Acute promyelocytic leukemia is characterized by the reciprocal translocation of chromosomes 15 and 17. All-trans retinoic acid (ATRA) efficiently induces differentiation of the abnormal promyelocytes. In this study, we had used ATRA as the primary induction therapy for 17 newly diagnosed patients,