Cytogenetic abnormalities involving the 11q23 region are found in both acute lymphoblastic leukemia (ALL) and myeloid leukemia (AML). Molecular consequences of 11q23 translocations are the formation of chimeric genes, all of them involving the MLL (mixed-lineage leukemia) gene. To evaluate the usefu
✦ LIBER ✦
Cytogenetic manifestation of chromosome 11 duplication/amplification in acute myeloid leukemia
✍ Scribed by Iveta Šárová; Jana Březinová; Zuzana Zemanová; Silvia Izáková; Libuše Lizcová; Eva Malinová; Adéla Berková; Jaroslav Čermák; Jacqueline Maaloufová; Ludmila Nováková; Kyra Michalová
- Book ID
- 113513732
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 524 KB
- Volume
- 199
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Gene amplification is a relatively rare event in acute myeloid leukemia (AML). Double minutes (dmin) and homogeneously staining regions are well established phenomena as cytogenetic correlates of gene amplification. Recently, however, two additional mechanisms leading to gene amplificat