Cytogenetic heterogeneity of pancreatic ductal adenocarcinomas: identification of intratumoral pathways of clonal evolution
✍ Scribed by María Laura Gutiérrez; José María Sayagués; María del Mar Abad; Oscar Bengoechea; María González-González; Alberto Orfao; Luís Muñoz-Bellvis
- Book ID
- 108781025
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 252 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0309-0167
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## Abstract Follicular lymphoma (FL) is characterized by the activation of __BCL2__ through t(14;18)(q32;q21). Additional acquired mutations are necessary to generate a fully malignant clonal proliferation. Many of these secondary genetic alterations are visible in the clonal karyotype; however, th
Twenty-nine nonendocrine pancreatic carcinomas (20 primary tumors and nine metastases) were studied by chromosome banding after short-term culture. Acquired clonal aberrations were found in 25 tumors and a detailed analysis of these revealed extensive cytogenetic intratumor heterogeneity. Apart from