Cytogenetic damage and induction of pro-oxidant state in human lymphocytes exposed in vitro to gliphosate, vinclozolin, atrazine, and DPX-E9636
✍ Scribed by Maria B. Lioi; Maria R. Scarfi; Antonietta Santoro; Rocchina Barbieri; Olga Zeni; Francesca Salvemini; Dino Di Berardino; Matilde V. Ursini
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 139 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0893-6692
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✦ Synopsis
We analyzed chromosome aberrations (CAs), sister experimental conditions, each chemical compound chromatid exchanges (SCEs), mitotic index (MI), tested produced a dose-related increase in the perand glucose 6-phosphate dehydrogenase (G6PD) cent of aberrant cells and an increase of SCE/cell. enzyme activity in human peripheral lymphocytes Furthermore, at the highest concentrations of vinclofrom three healthy donors exposed in vitro to differ-zolin, atrazine, and DPX-E9636, we observed a ent concentrations of gliphosate, vinclozolin, atra-significant reduction of the mitotic index. The inzine, and DPX-E9636. The pesticides gliphosate, crease of G6PD activity in exposed lymphocyte culvinclozolin, and atrazine have been studied in a tures strongly indicated an induction of a pro-oxibroad range of genetic tests with predominantly dant state of the cells as an initial response to pesticonflicting or negative results, whereas little is cide exposure.