Cytogenetic characterization of six malignant peripheral nerve sheath tumors: comparison of karyotyping and comparative genomic hybridization
✍ Scribed by Hannelore Schmidt; Helge Taubert; Peter Würl; Matthias Bache; Frank Bartel; Hans-Jürgen Holzhausen; Raoul Hinze
- Book ID
- 114135066
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 613 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0165-4608
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Peripheral nerve sheath tumors arise either sporadically or in association with neurofibromatosis type 1 (von Recklinghausen's neurofibromatosis, NF1) or type 2. In this study, comprehensive screening for relative chromosome copy number changes was performed on 10 benign and 19 malignant peripheral
We investigated 31 malignant peripheral nerve sheath tumors (MPNSTs) from 23 patients by means of comparative genomic hybridization (CGH) in order to study quantitative genomic aberrations of these tumors. Twenty-one of the 23 patients revealed changes, with a mean value of 11 aberrations per sample
Cytogenetic studies in small groups of patients with malignant peripheral-nerve-sheath tumors (MPNST) revealed complex karyotypes with no consistent changes. A computerassisted cytogenetic analysis using a cytogenetic database was performed to determine recurrent cytogenetic alterations in 51 MPNSTs