Cytogenetic and molecular analysis of a ring (21) in a patient with partial trisomy 21 and megakaryocytic leukemia
β Scribed by Palmer, C. G. ;Blouin, J.-L. ;Bull, M. J. ;Breitfeld, P. ;Vance, G. H. ;Van Meter, T. ;Weaver, D. D. ;Heerema, N. A. ;Colbern, S. G. ;Korenberg, J. R. ;Antonarakis, S. E. ;Chen, X.
- Book ID
- 102701561
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 958 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0148-7299
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W e recently began a cytogenetic and molecular study of nondisjunction in leukemic Down syndrome individuals to determine whether the mechanism by which the extra chromosome 21 originates predisposes the individual to leukemia. In the present report, we summarize our observations on I8 patients with
## Abstract Dystonia associated with chromosomal abnormalities is typically attributed to chromosomal deletions. We describe a patient with ring chromosome 21, with karyotype 46XX,r(21)(p11.2q22.3); 46,XX,dic r(21)(p11.2q22.3); 45, XX, β21, who developed childhood onset cervical dystonia. Β© 2003 Mo