Cytogenetic and histologic findings in 17 pulmonary chondroid hamartomas: Evidence for a pathogenetic relationship with lipomas and leiomyomas
✍ Scribed by Jonathan A. Fletcher; Janina Longtine; Kristin Wallace; Steven J. Mentzer; David J. Sugarbaker
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 393 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1045-2257
No coin nor oath required. For personal study only.
✦ Synopsis
Pulmonary chondroid hamartomas (PCH) are benign tumors that contain mesenchymal and epithelial components. In this series, we identified clonal chromosome aberrations in mesenchymal cells from 10 of 17 PCH. Chromosome band 12q15 was rearranged most frequently (N = 4), and one case had a t( 12;14)(qIS;q24) that was identical cytogenetically to the characteristic translocation in uterine leiomyomas. Histologic review revealed diverse mesenchymal populations, including undifferentiated cells, cartilage, adipose tissue, and smooth muscle, in most of the PCH. These findings suggest that PCH result from neoplastic transformation of a primitive mesenchymal cell that differentiates along chondroid, adipose, and smooth muscle pathways. Genes Chrornosom Cancer 12220-223 (1995). 0 I995 Wiley-Liss, Inc.