Cytogenetic analysis of murine cell lines from diethylstilbestrol-induced uterine endometrial adenocarcinomas

Use of representational difference analy

Use of representational difference analysis for the identification of mdm2 oncogene amplification in diethylstilbestrol-induced murine uterine adenocarcinomas

✍ John I. Risinger; Lori A. Terry; Jeff Boyd 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 861 KB

## Abstract Exposure in utero to the synthetic estrogen diethylstilbestrol (DES) is associated with the subsequent development of reproductive‐tract malignancies in female offspring. To search for the genetic targets of DES, representational difference analysis was used to compare genomic DNA from