Cytogenetic analysis of intestinal polyps in polyposis syndromes: Comparison with sporadic colorectal adenomas
โ Scribed by Constance A. Griffin; Sara Lazar; Stanley R. Hamilton; Francis M. Giardiello; Patricia Long; Anne J. Krush; Susan V. Booker
- Book ID
- 119105774
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 675 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0165-4608
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Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T
## BACKGROUND. Medulloblastomas can occur sporadically or may be associated with hereditary tumor syndromes including familial adenomatous polyposis (FAP) and nevoid basal cell carcinoma syndrome (NBCCS). ## METHODS. The authors performed a retrospective analysis for allelic deletion of the adeno