𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cytogenetic analysis of 101 skull base tumors

✍ Scribed by Ziv Gil; Avi Orr-Urtreger; Nadia Voskoboinik; Leonor Trejo-Leider; Ruth Shomrat; Dan M. Fliss

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
289 KB
Volume
30
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

Skull base tumors are rare neoplasms and the cytogenetic data on these tumors are limited. The authors cytogenetically analyzed a large series of tumors and compared the findings with patients' pathologic data.

Methods.

The karyotypes of pathologically confirmed samples of 101 patients, who were operated for oncological extirpation of tumors, were analyzed using G‐banding and spectral‐karyotyping techniques.

Results.

Of the 67 malignant tumors, 32 (48%) had chromosomal aberrations, some with complex numerical and structural chromosomal anomalies. Recurrent chromosomal breakpoints were identified in squamous cell carcinomas, adenoid cystic carcinomas (ACCs), sinonasal undifferentiated carcinomas, chordomas, and sarcomas. Specific breakpoints established the diagnosis of various soft tissue sarcomas. Novel chromosomal aberrations were found in various other malignant and benign tumors.

Conclusion.

This study highlights the value of cytogenetic analysis for diagnosis of skull base tumors. The data add further information on the biological behavior of these rare neoplasms. © 2007 Wiley Periodicals, Inc. Head Neck, 2008

📜 SIMILAR VOLUMES

Tumors of the skull base: Outcome and su
Tumors of the skull base: Outcome and survival analysis of 77 cases
✍ Dr. Jonathan C. Irish; Dr. Patrick J. Gullane; Dr. Fred Gentili; Jeremy Freeman; 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 755 KB

## Abstract We reviewed our experience with combined approaches to lesions that transcend the bones of the skull base. Seventy‐seven skull base procedures were performed on 73 patients during a 10‐year period from 1982 to 1992. There were 34 patients (44%) with region I lesions (anterior), seven pa

Three-dimensional MR reconstruction imag
Three-dimensional MR reconstruction images of skull base tumors
✍ Thomas J. Vogl; Josef Assal; Clifford Bergman; Gerd Grevers; Thomas Wustrow; Chr 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 984 KB

## Abstract Forty‐eight patients with skull base tumors were evaluated prospectively with T1‐weighted spin‐echo two‐dimensional (2D) magnetic resonance (MR) sequences, a three‐dimensional (3D) MR TurboFLASH (fast low‐angle shot) sequence, and a 3D reconstruction window technique. All patients under

Anterior skull base surgery for malignan
Anterior skull base surgery for malignant tumors: A multivariate analysis of 27 years of experience
✍ Brandon G. Bentz; Mark H. Bilsky; Jatin P. Shah; Dennis Kraus 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 84 KB 👁 1 views

## Abstract ## Introduction. Few studies have examined prognostic factors that have an impact on outcomes in anterior skull base surgery by multivariate analysis. ## Methods. We retrospectively examined our institution's skull base experience from 1973–2000. ## Results. During this time, 166 p