Cytogenetic analysis and flow cytometric DNA measurement of a human tumor with pronounced hypodiploidy
β Scribed by S.E. Petersen; P. Frederiksen; U. Friedrich
- Book ID
- 119102501
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 738 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Samples from 48 benign and 102 malignant bone and softβtissue tumors were analyzed cytogenetically and by DNA flow cytometry. Clonal chromosome abnormalities were found in 82 tumors and normal karyotypes in 68; 61 tumors were DNAβnonβdiploid and 89 were diploid. The cytogenetically abno
DNA histograms were measured by flow cytometry for 656 human solid tumors (365 primary and 291 metastatic). The proportion of aneuploid cells in cell suspensions obtained by mechanical disaggregation was significantly higher than those obtained after enzymatic disaggregation (collagenase + DNAse) of