Cytogenetic abnormalities in renal oncocytic neoplasms

✍ Scribed by Sheila M. Dobin; Charles P. Harris; Robert F. Peterson; V. O. Speights; James A. Reynolds; K. Scott Coffield; Richard C. Klugo

• Book ID: 102844536
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 649 KB
• Volume: 4
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870040104

✦ Synopsis

W e have performed cytogenetic studies on five renal oncocytic neoplasms (three grade 2 tumors and two grade I tumors) identified histologically by light microscopy. One grade I tumor failed to produce mitotic cells. The other four tumors exhibited both normal and abnormal cell lines. Numerical abnormalities were found in both the single grade I and two of the grade 2 tumors whereas structural abnormalities were limited to grade 2 tumors. Aneuploidy of chromosome I 2 was observed in both grade I and 2 tumors. Grade 2 tumors showed more extensive numerical change than the grade I tumors. Abnormalities of chromosome 3 characteristic of renal cell carcinoma were not found in any tumor in this series. A combination of C-banding and Hoelll endonuclease banding was used to identify an ambiguous marker. In our four cases and in the cases previously reported, loss of a sex chromosome, abnormalities of chromosomes I and 22, and trisomy I 2 are findings most often observed in renal oncocytoma. Genes Chrorn Cancer 425-3 I ( I 992).