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Cytogenetic abnormalities in an ossifying fibroma from a patient with bilateral retinoblastoma

✍ Scribed by Susanne M. Gollin; Patrick D. Storto; Patrick S. Malone; Janice A. Washington; Abirami Chidambaram; Leon Barnes; Ivo P. Janecka

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 698 KB
Volume: 4
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870040208

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✦ Synopsis

Cytogenetic analysis of a cemento-ossifying fibroma from a patient with nonfamilial bilateral multicentric retinoblastoma revealed three reciprocal translocations with the karyotype 46,XY,t( I; I8)(q2 I ;q2 I .3),t(3; I O)(p I3;q22).t(6; I I)(p22;p 15). Routine and high-resolution cytogenetic analysis of peripheral blood leukocytes showed an apparently normal, 46,XY chromosome pattern with no deletion of chromosome 13. Molecular analysis demonstrated no gross differences in the retinoblastoma gene or the Tf53 gene between constitutional and tumor DNA. This is the first cytogenetic analysis of a cementa-ossifying fibroma and the first report of this tumor in a retinoblastoma patient. The data may be added to the small, but growing literature on cytogenetic aberrations in benign tumors and may lend insight into genes involved in cell proliferation and neoplastic transformation. Genes Chrom Cancer 4: 146-152 (I 992).

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